I think the issue would be you should do a weight and balance to account for which version of the pants you have configured - rather than a blanket ON or OFF. It is not like they are on a MEL.
I'm probably missing something?......
Technically, the wheel pants are listed as a single line-entry on the option sheet from Cessna, with a single W&B figure for all three pants. Therefore, they can only be installed or removed as a set.